example of risk scoring


Polygenetic Analysis of Genetic Risk

Genetic testing has been available for a while for many conditions caused by a single gene, such as Huntington Disease or some forms of breast cancer. But most disabilities and health problems are caused by multiple genes, and new technology makes it possible to calculate genetic risk for diseases that have many contributing genetic factors, such as heart disease or schizophrenia.  What are the dangers of having such information? What are the advantages and disadvantages of using it as one basis of our system of medicine? What are the benefits and risks to different groups in society?


https://www.broadinstitute.org/news/depth-polygenic-risk-scoring


https://www.technologyreview.com/s/610251/forecasts-of-genetic-fate-just-got-a-lot-more-accurate/


http://interweave-consulting.blogspot.com/2016/03/a-polygenic-risk-for-autism-spectrum.html


https://qz.com/1035624/150-years-after-the-birth-of-the-eugenics-movement-researchers-are-carefully-dipping-back-into-the-genetics-of-social-mobility/


https://www.nature.com/articles/s41576-018-0018-x


https://www.nature.com/articles/s41591-018-0190-8


https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(17)30044-5/fulltext


https://onlinelibrary.wiley.com/doi/pdf/10.1038/sj.embor.7400224

 

https://www.genengnews.com/gen-exclusives/why-do-polygenic-risk-scores-get-so-much-hype/77901139

https://blogs.cdc.gov/genomics/2018/06/25/can-genetic-risk/

 

https://www.sciencedirect.com/science/article/pii/S0006322318314458

http://hw4sm7zh5k.scholar.serialssolutions.com/?sid=google&auinit=M&aulast=Spriggs&atitle=How+will+information+about+the+genetic+risk+of+mental+disorders+impact+on+stigma%3F&id=doi:10.1080/00048670701827226&title=Australian+and+New+Zealand+journal+of+psychiatry&volume=42&issue=3&date=2008&spage=214&issn=0004-8674


http://hw4sm7zh5k.scholar.serialssolutions.com/?sid=google&auinit=GJ&aulast=Hollands&atitle=The+impact+of+communicating+genetic+risks+of+disease+on+risk-reducing+health+behaviour:+systematic+review+with+meta-analysis&id=pmid:26979548


https://jamanetwork.com/journals/jama/fullarticle/2344586

https://www.plengegen.com/blog/tale-tails-polygenic/

http://www.bioethics.net/2017/11/is-your-polygenic-risk-score-a-good-thing/


https://www.technologyreview.com/s/609204/eugenics-20-were-at-the-dawn-of-choosing-embryos-by-health-height-and-more/

https://www.nytimes.com/2018/10/17/us/white-supremacists-science-dna.html