Two other botanists also claimed to
have independently rediscovered Mendelian genetics, but
Mendel gets credit because he actually laid out the theory
fairly completely
- Notice that Mendel, a monk who eventually became
head of the monastery, was doing experiments in the
context of Darwin's theory of evolution (probably to see
if crossbreeding could result in new species)
- He attended the University of
Vienna and did get to some scientific conferences
- he studied seven traits in pea plants that did
not average out
- if you bred a tall plant and a short plant you
initially got all tall plants, not plants half way in
between in height (because the gene for tallness is
dominant)
- in the next generation you get one short plant
for every three tall plants
- this is the simplest case when one gene
controls the trait, many traits are more complicated
because they are controlled by more than one gene
- what Mendel discovered most importantly was a
mathematical pattern, which wasn't yet that common in
biology
- it was known that peas tended to not average
traits, but it was not clear if this applied to other
plants and animals
- traits inherited together (linked traits) were
not widespread
- the scientific community had not yet realized
the need for Mendel's theory
- Mendel was ignored because he was not much known
and publishing in an obscure journal, but also because
there wasn't much need for the idea when he first
published it--heredity is rarely that simple
- the problem remaining once you have Mendelian
genetics is what exactly are genes?
You need both mutations and Mendelian genetics to
be able to show mathematically that evolution works, but
they were separate theories and people put them together
in different ways. There were a lot of mixed
theories: including or not including natural selection,
seeing genes as immaterial or located on chromosomes
Thomas Hunt Morgan proved that genes are on
chromosomes (early 1910s)
- studied fruit flies, which had the advantage of
a generation every 12 days
- he was initially looking for
mutations, and when he found one it bred true
according to Mendel's ratios
- he found linked traits but the links
sometimes broke; this could be explained by
recombination that can happen during meiosis, the
division of chromosomes for the egg or sperm cell
- they ended up being able to roughly
map the layout of genes on the chromosome, without
knowing what they were
- he saw mutations as creating new
species and didn't focus on natural selection
We still haven't gotten to the Modern Synthesis, of
genetics and Darwin's theory of evolution by natural
selection of small variations